The Society of Toxicologic Pathology (STP) Internet Committee-Web-based Education Subcommittee (WBEC) is pleased to offer these quarterly Short Education Webinar Series as an educational tool to foster collaboration among the toxicologic pathology community. The third of the series will focus on Cardiovascular Safety Assessment which features six presentations from a half-day Continuing Education Course at the STP Annual Symposium held in Boston, Massachusetts (June 2012).
These presentations will explore current understandings of mechanisms of toxicity in the cardiovascular system and put that understanding in the context of how we do our nonclinical assessments. An introductory overview will bring the audience to a common level of understanding around cardiovascular form and function, potential cellular and molecular targets of toxicity, and bridge into the compromised target patient population. Subsequent sessions will explore contemporary and mechanistically diverse areas of toxicity. Individual presentations will review our current level of understanding with respect to mechanisms of toxicity, review how current assessment paradigms address (or not) these mechanisms, and offer biomarker recommendations.
Michael C. Boyle, DVM, PhD, DACVP, DABT,
Amgen, Thousand Oaks, CA
Thomas Force, MD, Center for Translational Medicine,
Temple University School of Medicine, Philadelphia, PA
Heath C. Thomas, DVM, PhD, DACVP,
GlaxoSmithKline, Safety Assessment, King of Prussia, PA
Ingrid Pruimboom-Brees, DVM, PhD, DACVP,
Novartis Pharma AG, Basel, Switzerland
Michael Quaile, PhD, GlaxoSmithKline,
Laboratory Animal Sciences, Research Triangle Park, NC
Eric Schultze, DVM, PhD, DACVP, FIATP,
Lilly Research Laboratories, Indianapolis, IN