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STP Virtual Continuing Education Courses

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The Society of Toxicologic Pathology is offering three continuing education courses virtually in 2020. We will be submitting each course for RACE credits for attendance at the live webinar. All course registrants will also be able to download the course book a week prior to each webinar.

Ocotobe 12-14,2020 Modular Education Course

Vaccine Development from the Pathologist Perspective

Friday, August 28

Co-Chairs: Rani Sellers, DVM, PhD, DACVP, Pfizer Inc.; and Cynthia Rohde, PhD, Pfizer Inc.

The design and execution of toxicology studies supporting vaccine development have several unique elements relative to the conduct of traditional small molecule- or monoclonal antibody-supporting studies. This course is designed to give an overview of vaccine development, with emphasis on the regulatory guidances and special considerations in vaccine development (prophylactic and therapeutic), study design (including species selection), unique technical considerations, and anatomic and clinical pathology findings.

Introduction to Vaccine Developments
Cynthia M. Rohde, PhD, DABT, Pfizer Inc.

Animal Models to Support Vaccine Development
Rani Sellers, DVM, PhD, DACVP, Pfizer Inc.

Points to Consider in Vaccine Study Design and Implementation
Keith G. Nelson, DVM, PhD, DACVP, Charles River Laboratories

Anatomic and Clinical Pathology Interpretation and Correlations
Niraj K. Tripathi, BVSc, MVSc, PhD, DACVP, Covance; and Bindu Bennet, DVM, MSc, MS, PhD, Voyager Therapeutics

Coronaviruses and Vaccine Development
Rani Sellers, DVM, PhD, DACVP, Pfizer Inc.

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Course Registration

*A letter of verification from a department chair must accompany student registration.

STP Virtual Registration Fees
(per CE course)
STP Member $ 145
Nonmember $ 195
STP Student Member $ 45
Nonmember (Student) $ 75
STP Member Group Rate*
(Three or More from the Same Company)
$ 125
Nonmember Group Rate*
(Three or More from the Same Company)
$ 175
*To take advantage of the group rate please send your completed registration forms to
All three forms (or more) should be emailed at the same time.
Ocotobe 12-14,2020 Modular Education Course

Antibody Drug Conjugates (ADCs) as Cancer Therapies


Co-Chairs: William O. Iverson, DVM, Consultant; and Nancy E. Everds, DVM, DACVP, Seattle Genetics

Antibody-drug conjugates (ADCs), which use a specific antibody to deliver a toxic payload to target cells, hold great promise to increase efficacy and reduce adverse side effects, especially for oncology drugs. Six ADC molecules have received marketing approval in the US over the past 18 years. Nonclinical safety assessment has proven challenging as many ADCs still have steep dose-response curves and low therapeutic indices. Toxicities in many different organs and tissues have been seen, including bone marrow, skin, liver, kidney, eye, gastrointestinal tract, and nervous system. ADC-related toxicities may be more challenging to predict and manage than those seen with small molecules or unconjugated antibodies. This has led to more sophisticated engineering of antibodies, linkers, and drugs to increase internalization of drug by target cells, decrease off-target toxicity, and decrease bystander effects. This course will give an overview of synthesis and mechanisms of representative ADCs, and the clinical and anatomic pathology findings associated with different classes of agents, including immunomodulatory molecules and PROTACS.

Immune Modulatory Activity of Traditional and Nontraditional ADCs
Shyra J. Gardai, PhD, Seattle Genetics

Recent Progress in Antibody Drug Conjugates and PROTACs as New Modalities: Application to Oncology Drug Discovery
Lakshmaiah Gingipalli, PhD, AstraZeneca

Clinical Pathology Effects of Antibody Drug Conjugates in Toxicology Studies
Niraj K. Tripathi, BVSc, MVSc, PhD, DACVP, Covance

Anatomic Pathology Associated with Antibody Drug Conjugates
Matthew D. Smith, DVM, PhD, DACVP, Charles River Laboratories

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Ocotobe 12-14,2020 Modular Education Course

The Safeguarding of Your Vital Organ Systems Depends on Safety Pharmacology: What Is It?

(Sponsored by the American College of Toxicology)

FRIDAY, October 2

Co-Chairs: Michael K. Pugsley, MS, FBPhS, PhD, Cytokinetics; and Steve Tichenor, PhD, Charles River Laboratories

This continuing education course will include lectures that describe fundamental areas of safety pharmacology studies (CNS, Respiratory, Cardiovascular systems) for both new chemical entities (NCE) as well as biotechnology-derived products. It will also include some discussion of clinical issues (and methods) as well as novel non-clinical methods and approaches that may be added to the core ‘battery’ of tests used to explore the safety of novel therapeutic agents. Attendees will be introduced to discussion regarding the role safety pharmacology has as an integral component within the safety program for drug development. We will also introduce the Comprehensive In Vitro Proarrhythmia Assay (CIPA) cardiovascular paradigm being developed for hazard identification, elimination and risk assessment that would help to obviate conduct of the clinical “Through QT” (TQT) study. Furthermore, this course will provide attendees with a crucial resource that explains the important role safety pharmacology has in the overall pharmaceutical drug development process.

An Introduction to the Principles and Practice of Safety Pharmacology
Michael K. Pugsley, FBPhS, PhD, DSP, Cytokinetics

Core Battery 1: The Cardiovascular System
Michael K. Pugsley, FBPhS, PhD, DSP, Cytokinetics

Core Battery 2: The Central Nervous System
Susan M.G. Goody, PhD, Moderna Inc.

Core Battery 3: The Respiratory System
Steve Tichenor, PhD, Charles River Laboratories

A Safety Pharmacology Evaluation of Biopharmaceuticals
Michael J. Engwall, DVM, PhD, Amgen Inc.


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    Suite 300, Reston, VA 20191