Contact Information
  •   11190 Sunrise Valley Dr., Suite 300, Reston, VA, 20191
  •   stp@toxpath.org
  •   703-438-7508
open
Job Posting

Job Postings

Home / Careers/ Job Postings

Advertise on the STP website to reach your target audience effectively and economically!

Current Postings

Seattle Genetics, Bothell, WA—Discovery Pathologist

Posted:
Company: Seattle Genetics
Location: Bothell, WA
Job Title: Discovery Pathologist

Overview:

To meet the expanding needs of our company, Seattle Genetics is seeking an anatomic pathologist with exceptional scientific curiosity, critical thinking, and self-motivation to join our growing team within Translational Sciences. The position will focus on Discovery Pathology and support our strong early pipeline as we search for innovative new cancer therapeutics. You will be an integral driver for translating discovery research into the clinic, including target validation, target liability assessment, investigative toxicology, early lead screening, biomarker discovery, and development. Our company culture places a premium on scientific excellence, innovation, and teamwork.

You will contribute expertise to a highly skilled multidisciplinary team dedicated to helping cancer patients using both traditional and state-of-the-art pathology techniques, such as digital image analysis, multi-spectral imaging, or multiplex immunofluorescence. This team approach requires excellent interpersonal skills, clear communication, accountability, and self-motivation. To be successful in this science-based role, you must have exceptional critical thinking and problem-solving abilities. The position title and compensation package are flexible and will be determined based on the qualifications and experience level of the candidate.

Responsibilities:

  • Provide pathology expertise to facilitate target identification/validation, biomarker discovery/development, investigation of toxicities, and pharmacology discovery research
  • Design and conduct studies to investigate mechanisms of action of Seattle Genetics therapeutics and platforms
  • Interpret and report pathology endpoints to progress therapeutics through the pipeline from discovery to launch
  • Foster continued development of the group's pathology expertise through primary data generation or peer review of internal and external studies
  • Assist in identifying, evaluating, and implementing new technologies or techniques in our in-house pathology laboratories
  • Provide internal expertise to understand the mechanisms of toxicity observed non-clinically and/or clinically in order to drive mitigation and/or back-up strategies to minimize potential harm to patients
  • Present data and interpretations in written and oral form
  • Build collaborative networks both internal and external to the company to ensure rapid communication and cross-functional evaluations and investigation
  • Develop strong knowledge of the basic biology of Seattle Genetics targets and platforms and contribute to the development of the next generation of cancer therapeutics
  • Represent Seattle Genetics in the external scientific environment

Qualifications:

  • 3–10 years of pathology experience in an academic or pharmaceutical/biotech setting
  • Demonstrated skills in critical thinking, problem solving, and mechanistic investigation evidenced by scientific publications or presentations
  • Understanding of and experience with basic and advanced tissue-based investigative techniques such as immunohistochemistry, in situ hybridization, immunofluorescence, digital image analysis, electron or confocal microscopy, laser capture microdissection, etc.
  • Experience applying research techniques to drug discovery and development

Education and Certification:

  • D.V.M. (or equivalent)
  • Ph.D. in toxicology, pathology, comparative biology, or a related field
  • Diplomate, American College of Veterinary Pathologists (or equivalent) in anatomic pathology

As the leading employer in our industry in the Pacific Northwest, Seattle Genetics is proud to offer a competitive total compensation package as well as a comprehensive benefits program designed to support the whole lives of our employees and their families. Benefits include medical, vision and dental coverage, group and supplemental life insurance, 401(k) with company match, tuition reimbursement, relocation assistance and much more. To learn more about Seattle Genetics, please visit www.seattlegenetics.com.

Novartis Institutes for BioMedical Research, Inc., Cambridge, MA—Pathologist, NIBR Oncology Translational Research

Posted:
Company: Novartis Institutes for BioMedical Research, Inc.
Location: Cambridge, MA
Job Title: Pathologist, NIBR Oncology Translational Research

The Oncology Translational Research group at NIBR is recruiting a research-oriented pathologist to provide scientific and clinical expertise to inform patient selection strategies and biomarker development. You will partner across the full range of Oncology programs (small molecule, biotherapeutics and Immuno-Oncology) from target identification through First-in-Human studies.

Responsibilities:

  • Provide strategic scientific and clinical input to the Oncology Pathology & Biomarkers group and project teams locally and internationally
  • Work closely with research and early clinical project teams (Scientists and Physician-Scientists) to design and interpret slide and human tissue-based experiments; evaluate biomarkers in human and xenograft samples via techniques such as IHC, ISH, IF, LCM, and protein assays
  • Explore utility of innovative tissue-based technologies for drug discovery (e.g. deep learning on digital pathology images, mass cytometry imaging, spatial transcriptomics)
  • Lead scientific associates to design and conduct experiments, to interpret and challenge experimental results
  • Network internally and externally with other pathologists, clinicians and scientists on project activities
  • Engage in independent research with colleagues across Oncology Translational Research and broader Novartis Institutes for BioMedical Research Disease Areas and Translational Medicine groups
  • Author internal reports and presentations
  • Champion writings of external publications and patent applications
  • Conduct and supervise your lab to ensure compliance with HSE guidelines and policies

Desirable Requirements:

  • Candidates must have an MD, MD/PhD, or DVM/PhD with formal training in anatomic pathology. Hematopathology fellowship or experience characterizing immune infiltrates preferred.
  • Demonstrated expertise in tissue-based analysis, such as interpretation of IHC, interpretation of tissue microarrays, and image analysis.
  • Working knowledge of DNA/RNA based methodologies for tissue-based analysis preferred.
  • Demonstrated success in supervising technical staff.
  • PhD-level research experience in pathology, molecular genetics, immunology or related field preferred.
  • Excellent communication skills (written and oral).
  • The ideal candidate will be collaborative, innovative, and self-directed, with outstanding teamwork capabilities.

Why consider Novartis?

750 million.

That’s how many lives our products touch. And while we’re proud of that fact, in this world of digital and technological transformation, we must also ask ourselves this: how can we continue to improve and extend even more people’s lives?

We believe the answers are found when curious, courageous and collaborative people like you are brought together in an inspiring environment. Where you’re given opportunities to explore the power of digital and data. Where you’re empowered to risk failure by taking smart risks, and where you’re surrounded by people who share your determination to tackle the world’s toughest medical challenges.

We are Novartis. Join us and help us reimagine medicine.

Please visit the link to review the complete job description and to apply online.

StageBio, Remote—Anatomic Veterinary Pathologist

Posted:
Company: StageBio
Location: Remote
Job Title: Anatomic Veterinary Pathologist

Overview:

StageBio (www.stagebio.com) is a leading provider of GLP-compliant research and preclinical histology, pathology and specimen archiving services for the biopharmaceutical, medical device and contract research industries. We operate locations in VA, OH, MA and MD, with continued investment in facility and technology infrastructure planned to meet the demand for high-quality histopathology services. A growing team of 20+ board-certified Veterinary Pathologists, as well as over 50 laboratory technicians, are employed in support of our unified commitment to quality, scientific integrity and client satisfaction.

StageBio is seeking full-time, experienced, board-certified veterinary pathologists primarily for remote working arrangements, although on-site positions in one of our four locations may be arranged. Routine toxicologic pathology experience is required, and all related areas of special expertise are welcomed. The ideal candidate for these positions appreciates a high level of study variety and is suited to work in a flexible environment where technology is used not only for scientific purposes but also to keep the pathology team connected.

Responsibilities:

  • Perform routine anatomic pathology evaluation, including microscopic tissue assessment and report authoring, for both non-GLP and GLP toxicology studies.
  • Serve as Study Pathologist for assessment and reporting of anatomic pathology findings in accordance with protocol requirements.
  • Work with internal staff to meet reporting deadlines and maintain productive collaborations with clients.
  • Provide occasional necropsy supervision duties and/or other off-site assignments as required.
  • Ensure GLP compliance for all work performed.
  • Interact with Study Directors/clients as needed.
  • Maintain continuing education through professional association affiliations, participation in relevant conferences and/or publication efforts.
  • Participate in Pathology Peer Review as needed.

Requirements:

  • DVM/VMD degree and ACVP (Anatomic Pathology) board certification. PhD or MS welcomed but not required.
  • Minimum of 5 years of work experience as a board-certified veterinary pathologist in a GLP research and/or toxicology environment.
  • Ability to travel for professional meetings and/or occasional necropsy services.
  • Experience with commercial pathology data capture software.
  • Experience capturing, annotating, and sharing routine photomicrographs (from microscope/camera combination).
  • Experience responding to GLP pathology report audits.
  • Excellent technical writing and communication skills.
  • Experience with GLP peer reviews (preferred).

StageBio offers a comprehensive benefits package that includes employee sponsored health insurance, dental insurance, vision insurance, short-term and long-term disability, AD&D, and life insurance for employees and dependents. StageBio is an equal opportunity employer.

If you are interested in hearing more about this opportunity or would like to apply for this position, please contact HR@stagebio.com.

Alnylam Pharmaceuticals Inc., Cambridge, MA—Program Toxicologic Pathologist

Posted:
Company: Alnylam Pharmaceuticals Inc.
Location: Cambridge, MA
Job Title: Program Toxicologic Pathologist

Overview:

Alnylam was founded in 2002 on a revolutionary vision and bold mission which remain firmly in place today. We are leading the translation of RNA interference (RNAi) into a new class of innovative medicines with the potential to transform the lives of people with rare genetic, cardio-metabolic, hepatic infectious, and central nervous system diseases with unmet need. Our first medicine, the first-ever RNAi therapeutic, has recently been approved by the FDA in the US for the treatment of the polyneuropathy of hereditary transthyretin-mediated amyloidosis in adults and by the European Medicines Agency in the EU for the treatment of hATTR amyloidosis in adults with stage 1 or stage 2 polyneuropathy. In addition, Alnylam has four investigational medicines in late-stage development. www.alnylam.com. Alnylam is proud to have been recognized as one of The Boston Globe’s Top Places to Work in 2015, 2016, 2017 and 2018- four years in a row!

Alnylam has a full-time opening for a Toxicologic Pathologist with demonstrated expertise in drug development. The company’s pipeline has recently expanded beyond traditional liver indications to include both CNS and Ocular indications. Therefore, a successful candidate must be able to provide expert pathology support, scientific leadership and play an active role in the process of drug development from early-stage research through marketed products across several therapeutic areas/indications. In this position, you will play a pivotal role across a broad range of existing and emerging projects through the design, implementation and data analysis for both investigative and research studies. Qualified individuals will also participate in pathology oversight for regulatory toxicology studies, including the evaluation clinical pathology data, primary histopathology evaluations for in-house studies, and pathology peer review for GLP studies conducted at CROs. The successful candidate will have an opportunity to participate on drug development teams, overseeing the design and execution of studies, and generation of regulatory strategy and communications with global regulatory agencies to support development of drug development candidates.

Summary of Key Responsibilities:

  • Conduct gross and microscopic examination of animal tissues from toxicology and investigative studies, interpret and determine the significance of results for clinical pathology, organ weight, necropsy and histopathology data
  • Provide concise written pathology reports that accurately and completely reflect the data collected and the impact on drug development, drug registration and human safety
  • Represent the Early Development group on early program teams supporting research and development projects
  • Conduct pathology peer reviews of GLP studies at CROs
  • Assist in the regulatory toxicology strategy, guiding development and project prioritization by responding quickly to data from ongoing studies and providing input to management and development teams
  • Summarize experimental results for presentations both within and outside of the company

Qualifications:

  • Doctor of Veterinary Medicine (DVM)
  • Residency or other specialty training in anatomic / toxicologic pathology
  • ACVP-board certification in anatomic pathology
  • 3-5 years of experience as a pathologist in biotech, pharma or at a CRO
  • Experience working in a GLP-compliant environment
  • PhD in Toxicology or Pathology, or another relevant field of expertise, is strongly preferred
  • Level commensurate with training and experience level of the individual.

Alnylam Pharmaceuticals is an EEO employer committed to an exciting, diverse, and enriching work environment.

Please visit the link to review the complete job description and to apply online.

Charles River Laboratories, Multiple Listings—Veterinary Pathologist

Posted:
Company: Charles River Laboratories
Location: Multiple Listings
Job Title: Veterinary Pathologist

We currently have openings for a Veterinary Pathologist II and a Senior Veterinary Pathologist in locations in Canada and across the United States.

Responsibilities:

  • Perform macroscopic and microscopic tissue evaluation and interpretation of assigned studies.
  • Record pathology findings in data capturing system(s).
  • Prepare complex reports delineating pathological findings and detailing all test article effects
  • Interact with clients to assure satisfaction and to market services.
  • May assist with necropsy supervision and may conduct necropsies, including gross pathology interpretation, sample collection and fixation.
  • As needed, work with study directors to ensure data is accurately integrated into study reports.
  • Provide training, technical guidance and leadership to laboratory staff and to less experienced pathologists, as needed.
  • Provide advanced scientific expertise for experimental design and other aspects of research studies as needed.
  • Perform all other related duties as assigned.

Requirements:

  • Education: Doctoral degree (D.V.M./V.M.D.) from an accredited veterinary school, or acceptable international equivalent in veterinary medicine.
  • Certification/Licensure: American or European College of Veterinary Pathologists (A.C.V.P; E.C.V .P) board-certification required.
  • Experience: 1 or more years of pathology experience post ACVP/ECVP certification; specialized training and/or experience in toxicology pathology preferred.
  • An equivalent combination of education and experience may be accepted as a satisfactory substitute for the specific education and experience listed above.
  • Other: Able to work on complex problems in which analysis of situations or data requires an in-depth evaluation of various factors. Has demonstrated success in technical proficiency, scientific creativity, collaboration with others and independent thought; has a reputation as an emerging leader with sustained performance and accomplishment.
  • Computer literacy in word processing, spreadsheet and database software
  • Working knowledge of French preferred

For this position, we have locations in Canada and all over the United States.

For our Veterinary Pathologist II positions, please apply to the following locations:

For our Senior Veterinary Pathologist positions, please apply to the following locations:

West Tennessee Regional Forensic Center, Memphis, TN—Chief Medical Examiner

Posted:
Company: West Tennessee Regional Forensic Center
Location: Memphis, TN
Job Title: Chief Medical Examiner

The WTRFC performs approximately 1,000 autopsies per year for 13 counties west of the Tennessee River. The center encounters a wide variety of cases, including traumatic deaths, toxicological deaths, and natural deaths. The Chief Medical Examiner will perform death investigations, establish cause and manner of death, formulate conclusions, opinions or testimony in judicial proceedings, and to be available for consultations as necessary.

Duties and Responsibilities:

  • Responsible for directing the overall operation of the West Tennessee Regional Forensic Center by performing highly responsible and complex administrative work in planning, coordinating, directing, implementing and controlling the statutory functions as defined by the Tennessee Post-Mortem Examination Act; and to do related work as required
  • Provide direct or indirect services to District Attorneys, the Courts, the Attorney General, funeral homes, families of decedents, hospitals and major medical academic centers, insurance companies, organ procurement organizations, local and state police investigators, fire departments, a variety of state agencies, and various Federal programs and agencies.
  • Coordinate activities of the West Tennessee Regional Forensic Center with the Shelby County Department of Health.
  • Responsible for directing the overall operation of the Medical Examiner's Office which carries out medicolegal death investigations for the County, and provides autopsy services for up to 15 other counties in the north, central and eastern portions of the state.
  • Perform the responsibilities of a forensic pathologist (i.e. doing autopsies) and responsible for reviewing the forensic pathology functions done in the setting.
  • Counsels’ families in person or thru the telephone on increasing their level of understanding regarding the cause and manner of the death of the person involved as well as the psychological and physiologic aspects of the case.
  • In certain circumstances, the Chief Medical Examiner may be obligated to be a witness in the courts of law to aid in investigation of cases.

Qualifications:

  • Education: Graduation from an accredited medical school and board certification in Forensic Pathology by the American Board of Pathology
  • Experience: Minimum of 8-10 years of experience in a responsible position involving practice in the field of Forensic Pathology, prior management experience is required. OR, any combination of education and experience that shall be substantially equivalent to the above education and experience
  • License/Certification: Must possess licensure to practice medicine and certification by the American Board of Pathology in the field of Anatomic Pathology and Forensic Pathology at the time of appointment and must maintain such licensure and certification as a condition of employment.
Please visit the link to review the complete job description and to apply online.

Vertex Pharmaceuticals Inc., Boston, MA—Director, Investigative Toxicologic Pathologist

Posted:
Company: Vertex Pharmaceuticals Inc.
Location: Boston, MA
Job Title: Director, Investigative Toxicologic Pathologist

Preclinical Safety Assessment (PSA) is a global function responsible for the design and conduct of comprehensive nonclinical safety programs for the evaluation of Vertex therapies at all stages of discovery and development. Vertex Pharmaceuticals uses cutting edge science and technology to perform robust assessments of novel therapies for the treatment of the most serious diseases with unmet medical need. Our culture enables individual empowerment where ‘We Wins, Fearless Pursuit of Excellence, and Innovation’ are more than just corporate values; they are part of our everyday lives. PSA pathologists have significant roles in the drug development process beginning in early discovery and continuing through the entire drug development value chain resulting in successful registration and marketing approval.

Key Responsibilities:

  • Strategic and scientific leadership in the design, conduct and interpretation of pathology endpoints for animal model development, target identification/validation, and in vivo pharmacology and nonclinical biomarker development studies including the use of cutting-edge molecular diagnostic and digital imaging technologies as part of a newly created discovery & investigative pathology group
  • Anatomic pathology evaluation of investigative pathology and regulatory toxicity studies from lead identification/optimization through registration and post-marketing including peer review of outsourced nonGLP and GLP toxicology studies
  • Expert scientific leadership in discovery, translational research, and regulatory nonclinical safety profiling activities as a key partner on cross-functional teams within Vertex, working with a high-functioning multidisciplinary team of preclinical safety and biomarker scientists including a Board-certified veterinary clinical pathologist and an extensive network of external consultants and contract research organizations
  • Participation in regulatory submission document preparation, poster presentations and scientific publications, including addressing queries from global health authorities

The position includes opportunities for potential additional roles including:

  • Preclinical safety representative on discovery and/or development project teams
  • Nonclinical safety evaluation of in-licensing opportunities supporting business development

Minimum Qualifications:

  • DVM or equivalent and ACVP/ECVP board certification in veterinary anatomic pathology.
  • PhD in a relevant scientific discipline is strongly preferred
  • 3+ years of work experience in Discovery and/or Toxicologic pathology in the pharmaceutical/biotechnology sector including the conduct of GLP peer reviews
  • Extensive practical experience using imaging technologies and molecular diagnostic pathology techniques to understand the pathologic basis of disease and support drug discovery and development
  • Demonstrated excellence in oral and written communications, critical thinking and issue resolution skills, and scientific collaboration, guidance, and mentoring of non-DVM scientists and laboratory associates

Vertex is a global biotechnology company that aims to discover, develop and commercialize innovative medicines so people with serious diseases can lead better lives. In addition to our clinical development programs focused on cystic fibrosis, Vertex has more than a dozen ongoing research programs aimed at other serious and life-threatening diseases.

Please visit the link to review the complete job description and to apply online.

Regeneron Pharmaceuticals, Tarrytown, NY—Senior Research Pathologist/ Fellow, Pathology

Posted:
Company: Regeneron Pharmaceuticals
Location: Tarrytown, NY
Job Title: Senior Research Pathologist/ Fellow, Pathology

Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases.

Summary:

DVM, PhD, board certified (DACVP) Anatomic Pathologist with solid experience assessing tissues from investigative pathology and regulatory toxicology studies. The selected individual will have primary responsibility for pathology peer review of regulatory studies conducted at CROs. Using the standard tools of histopathology and immunohistochemistry (IHC) and the more novel tools of RNA/Scope, the pathologist will also be expected to furnish pathology support for Discovery efforts in a variety of therapeutic focus areas (TFAs) including: Inflammation/Immune Diseases, Neuroscience/Pain, Oncology/Angiogenesis, Infectious Diseases, Ophthalmology, Obesity/Metabolic Diseases, Skeletal, Muscle and Genetic Diseases, as well as Cardiovascular/Renal/Fibrosis. In addition, the successful individual will provide leadership in the utilization of the Aperio System and its suite of powerful viewing and analysis tools to support digital pathology productivity at Regeneron.

Responsibilities:

  • Reports to the Senior Director/ Head of Pathology.
  • Participates in strategy development in Drug Safety and Pharmacometrics (DSP) through advocacy for the Pathology components of regulatory/research studies
  • to help design, develop, and implement research programs to support facets of drug development in alignment with REGN’s varied initiatives.
  • Utilizes mastery level skills in anatomic, toxicologic and molecular pathology and strategic leadership to design and execute research and development projects within and outside own discipline. Is influential in developing project strategy — provides intellectual vision and guidance.
  • Provides expert histopathology, IHC and RNAScope evaluation support for the phenotypic characterization of REGNs animal disease and in vivo drug efficacy models
  • Performs GLP-compliant peer review of the pathology aspects of REGN toxicology studies at CROs
  • Provides expert translational pathology consultation to project teams to facilitate interpretation of preclinical data in the context of human diseases
  • Collaborates on teams to develop predictive and prognostic biomarkers in support of REGN pipeline drugs.
  • Collaborates with other Pathologists to develop a strong in-house digital pathology program
  • Makes a contribution to multidisciplinary meetings. Shares cross-functional skills and knowledge at a wide variety of meetings. Initiates and edits multi-contributor internal and/or external "publications" (i.e., Peer Reviewed publications, SOP’s, Patents, Business Plans, etc.). Prepares reports, presentations and manuscripts. Disseminates study findings to toxicologists, research investigators, project teams and others, including at national and international seminars as needed.

Requirements:

  • At least 2 (Senior Research Pathologist)/5 (Fellow, Pathology) years of toxicologic pathology experience that should ideally include drug discovery support.
  • Clear demonstration of high-quality scholarly productivity in investigative pathology or other areas of biomedical research evidenced by publications is desirable.
  • The ideal candidate must have demonstrated ability to handle regulatory as well as discovery projects and worked successfully in a variety of therapeutic projects teams.
  • Experience with large molecule projects will be an advantage.
  • The successful candidate will be familiar with, if not expert in molecular pathology and image analysis techniques and will have excellent verbal and written communication skills.
  • Minimal educational requirements: Ph.D./ DVM/ Board Certified DVM Pathologist

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.

Please visit the link to review the complete job description and to apply online.

Covance, Chantilly, VA—Veterinary Anatomic Pathologist

Posted:
Company: Covance
Location: Chantilly, VA
Job Title: Veterinary Anatomic Pathologist

Covance is Hiring!

Are you passionate about advancing your career while making a difference in patient’s lives?

Are you looking for an exciting career with room for growth within a supportive team?

If you answered yes to these, we’d like you to consider joining Covance. We have Veterinary Anatomic Pathologist positions open at our following sites:

  • Chantilly, Virginia
  • Harrogate, United Kingdom
  • Münster, Germany

Come join a global team of veterinary pathologists focused on providing high quality support to nonclinical studies spanning all phases of drug development.

Covance’s work in developing new pharmaceutical solutions has an incredible impact on millions of lives worldwide. Be a part of this life-saving work.

If interested in learning more about these opportunities, please contact tricia.cullen@covance.com

Apply Online

Takeda, Boston, MA—Associate Scientific Director, Pathology

Posted:
Company: Takeda
Location: Boston, MA
Job Title: Associate Scientific Director, Pathology

As an Associate Scientific Director, Pathology you will be empowered to provide pathology and toxicology expertise and collaborate with Global Head of Pathology and Drug Safety Therapeutic Leaders. A typical day will include:

Objectives:

  • Provide pathology and toxicology expertise and represent DSRE on discovery, research and development project teams
  • Collaborate with Global Head of Pathology and Drug Safety Therapeutic Leaders in the development and execution of strategies for discovery and development programs
  • Provide stewardship, toxicology and/or pathology support and interpretation of toxicology studies on drug candidates with subsequent preparation and review of regulatory documents and support of Regulatory Affairs and Clinical groups for all phases of development, including IND through registration across all therapeutic indications
  • Develop talent and mentor junior toxicologists or pathologists (Global) and the Comparative Medicine in vivo toxicology group (Cambridge site only)
  • Scientific leader with deep subject-matter expertise, driving project team progression and development of technical capabilities

Accountabilities:

  • Evaluate histopathology specimens from a variety of nonclinical animal species used in nonclinical toxicity studies to determine target organs and morphologic toxicity profile of potential novel pharmaceutical agents.
  • Conduct peer reviews of pathology data generated off-site.
  • Provide histopathology support for peripheral experimental modalities used in other departments such as immunohistochemistry and xenograft tumor models.
  • Serve on project teams for drug discovery, transition and development teams
  • Design and interpret toxicology studies to address human safety concerns and relevance
  • Review study reports and regulatory documents for technical accuracy and regulatory adequacy
  • Prepare regulatory documents (BB, IND, IB, DSUR, BLA, MAA, NDA, JNDA) and respond to health authorities concerning toxicology issues
  • Collaborate and interface with project leaders across Takeda to ensure transition of programs into development
  • Develop strategies for addressing toxicology issues and present them to management and governance committees
  • Work with CMC to qualify impurities as needed
  • Work with Comparative Medicine in vivo toxicology group on issues regarding in vivo studies and the 3Rs
  • Participate in local and national toxicology/pathology meetings and represent Takeda at these meetings
  • Independently manages workload and expectations Scientifically
  • Independent Scientific driver for research strategy that impacts group internally and outside area of function

Education, Experience, Knowledge and Skills:

  • DVM and PhD degree in a scientific discipline with 10+ years experience, or MS with 14+ years experience, or BS with 16+ years experience
  • Pharmaceutical drug development experience including as a project team representative (5+)
  • Proficiency in histopathology
  • In-depth understanding of molecular biology
  • Excellent communication skills (written and oral)
  • Ability and desire to take on leadership roles
  • Ability to team with colleagues across different functional areas
  • Proficiency with computer systems such as word processing, spreadsheets and databases

Licenses/Certifications:

  • Certification in veterinary pathology (ACVP, ECVP, or JCVP)
  • Certification in toxicology (ABT or equivalent) - optional

Physical Demands:

  • Routine demands of an office based environment.

Travel Requirements:

  • Willingness to travel to various meetings or client sites, including overnight trips. Some international travel may be required.

What Takeda Can Offer You:

  • 401(k) with company match and Annual Retirement Contribution Plan
  • Tuition reimbursement
  • Company match of charitable contributions
  • Health & Wellness programs including onsite flu shots and health screenings
  • Generous time off for vacation and the option to purchase additional vacation days
  • Community Outreach Programs
Apply Online

Alnylam Pharmaceuticals, Cambridge, MA—Toxicologic Pathologist, Neuropathology

Posted:
Company: Alnylam Pharmaceuticals
Location: Cambridge, MA
Job Title: Toxicologic Pathologist, Neuropathology

Job Description:
Alnylam was founded in 2002 on a revolutionary vision and bold mission which remain firmly in place today. We are leading the translation of RNA interference (RNAi) into a new class of innovative medicines with the potential to transform the lives of people with rare genetic, cardio-metabolic, hepatic infectious, and central nervous system diseases with unmet need. Our first medicine, the first-ever RNAi therapeutic, has recently been approved by the FDA in the US for the treatment of the polyneuropathy of hereditary transthyretin-mediated amyloidosis in adults and by the European Medicines Agency in the EU for the treatment of hATTR amyloidosis in adults with stage 1 or stage 2 polyneuropathy. In addition, Alnylam has four investigational medicines in late-stage development—www.alnylam.com. Alnylam is proud to have been recognized as one of The Boston Globe’s Top Places to Work in 2015, 2016, 2017 and 2018—four years in a row!

Alnylam has a full-time opening for a veterinary pathologist with demonstrated experience/expertise in neuropathology and the ability to provide support, scientific leadership and guide both early-stage research and development programs. The successful candidate will participate across a broad range of existing and emerging projects through the design, implementation and data analysis for both investigative and research studies. Qualified individuals may also participate in pathology oversight for regulatory toxicology studies, including evaluating drug safety clinical pathology data, and performing pathology peer review for GLP studies conducted at CROs. The successful candidate will have an opportunity to participate on drug development teams, overseeing the design and execution of studies, and generation of regulatory strategy and communications with global regulatory agencies to support development of drug development candidates.

Summary of Key Responsibilities

  • Experience evaluating studies utilizing both standard routes (intravenous and subcutaneous) of administration and intra-thecal (IT) and intra-cerebroventricular (ICV) routes.
  • Expertise with a range of routine and advanced investigative/research pathology techniques related to studying distribution, activity and or toxicity of compounds in the central and peripheral nervous systems.
  • Experience with animal models of neurologic disease and the development of translational biomarkers for the central and peripheral nervous systems.
  • Conduct gross and microscopic examination of animal tissues from toxicology and investigative studies, interpret and determine the significance of results for clinical pathology, organ weight, necropsy and histopathology data.
  • Provide concise written pathology reports that accurately and completely reflect the data collected and the impact on drug development, drug registration and human safety.
  • Experience as a program pathologist and the conduct pathology peer reviews of GLP studies at CROs is highly desirable.
  • May assist in the regulatory toxicology strategy, guiding development and project prioritization by responding quickly to data from ongoing studies and providing input to management and development teams.
  • Summarize experimental results for presentations both within and outside of the company.

Qualifications:

  • • Doctor of Veterinary Medicine (DVM)
  • • Residency or other specialty training in anatomic/toxicologic pathology
  • • ACVP or ECVP-board certification in anatomic pathology
  • • 5+ years of experience as a pathologist in either research, biotech, pharma or CRO environment
  • • Experience working in a GLP-compliant environment is desirable
  • • Excellent oral and written communication skills
  • • PhD in Neuroscience, Toxicology, Pathology, or another relevant field of expertise, is strongly preferred
  • • Level commensurate with training and experience level of the individual.

Alnylam Pharmaceuticals is an EEO employer committed to an exciting, diverse, and enriching work environment.

Apply Online

Charles River Laboratories, Reno, NV—Clinical Pathologist II

Posted:
Company: Charles River Laboratories
Location: Reno, NV
Job Title: Clinical Pathologist II

Job Summary:
Charles River Laboratories–US Safety Assessment is seeking to hire a clinical pathologist for our Reno, NV site. Charles River Laboratories-Nevada employs a multidisciplinary group of scientists and technical staff that conduct investigative and IND-enabling preclinical studies in non-human primates and rats for drug development for pharmaceutical companies. The clinical pathology laboratory is equipped for hematology, clinical chemistry, coagulation, urinalysis and other specialty analyses. The successful candidate will join locally a staff of board-certified clinical pathologists, a laboratory staffed by multiple medical technologists, about 20 support technicians, and a global group of 15 board-certified clinical pathologists located in the U.S., Canada and France. Additionally, the Clinical Pathology Department in Nevada interacts with a highly qualified staff of board-certified anatomic pathologists, toxicologists, and veterinarians.

The following are minimum qualifications related to the Clinical Pathologist II position:

Qualifications:

  • Education: D.V.M. / V.M.D. (Doctor of Veterinary Medicine) degree required. Ph.D. in Clinical Pathology or related discipline preferred.
  • Experience: Experience in clinical pathology or experimental pathology preferred.
  • Certification/Licensure: Board certification by the American College of Veterinary Pathologists (D.A.C.V.P.) Specialty in Clinical Pathology required.
  • Other: Full understanding of regulatory requirements, Good Laboratory Practices (GLPs), site SOPs, and of study types assigned. Knowledge of applicable international guidelines for all types of toxicology studies. Demonstrate leadership skills as they pertain to intra- and interdepartmental initiatives, Sponsor interactions, and business development. Effective written and verbal communication skills. Ability to handle multiple projects, prioritize work and meet deadlines. Proficiency in the use of standard software including Microsoft® Excel, Word, PowerPoint, etc. and with standard laboratory calculations and statistical interpretation.

Charles River Laboratories–Nevada is located in Reno, Nevada and is approximately 45 minutes from Lake Tahoe. Charles River Laboratories offers a competitive salary and excellent benefits. To apply, interested candidates should visit us at http://jobs.criver.com/reno-jobs.

Apply Online

Apple Inc., Cupertino, CA—Senior Toxicologist / Senior Biocompatibility Engineer - 200038754

Posted:
Company: Apple Inc.
Location: Cupertino, CA
Job Title: Senior Toxicologist / Senior Biocompatibility Engineer - 200038754

Job Summary:
Imagine what you could do at Apple. Do you care about how products perform, what makes them delightful yet keeps them safe and user-friendly in the deepest sense? Do you ever consider how much attention is put into Apple’s product design allows us to uphold user trust and confidence? The engineering team in Apple’s cutting-edge Product Safety group is responsible for ensuring our products meet international safety standards and regulations, but also exceed those requirements to befit Apple’s expectations.

Apple's Safer Materials and Biocompatibility team is seeking a toxicology professional to conduct toxicological assessments of materials used in the production of Apple products. We will look to you to identify substances that may be potentially hazardous to human health. You will work closely with Apple’s product design teams, program managers, and suppliers to track the use of materials, identify substances of concern, investigate safer alternatives, and support implementation of chemical substitution programs.

Key Qualifications:

  • Minimum of 3 years relevant industry experience in toxicology or equivalent field
  • Expertise in hazard identification, skin irritation/sensitization, risk assessment of substances, including alternative risk assessment methodologies
  • Experience with ISO 10993 and assessing materials for biocompatibility
  • Knowledge/experience with alternative testing methodologies and prediction models
  • Experience building dossiers, developing SOPs & test protocols
  • Excellent communication and presentation skills to technical and non-technical audiences
  • Proven ability to excel in a dynamic, schedule-driven environment

Description:
This position is offered in Apple's Environmental Technologies group of Apple's Hardware Engineering division. Our mission is to deliver the world's leading programs on the elimination of hazardous substances, improved material and energy efficiency, as well as design for environment. Apple believes that major improvements in environmental performance will be delivered through product design innovations.

We rely on your expertise in assessments on the toxic nature of chemical substances of materials used in the manufacture of wearable and non-wearable products that meet the prolonged skin contact requirements. You will focus primarily on the calculation of exposure to chemical substances, evaluation of their inherent hazardous properties, and identification of potential risks from the use of materials in Apple products and processes. You will be a major contributor in building Apple specifications, policies, and processes that place limitations on substances that are potentially hazardous to human health. You will contribute to the development of novel test methodologies to identify restricted substances and potential risks. You will also work with cross-functional partners, program managers and suppliers towards alternative assessments that identify safer substances and support substitution programs with suppliers.

Education:

  • PhD in toxicology or related field with 3 + years experience in an industry setting
  • MS in toxicology or related field with 10 + years experience in an industry setting
  • DABT certification is a plus
Apple is an Equal Opportunity Employer that is committed to inclusion and diversity. We also take affirmative action to offer employment and advancement opportunities to all applicants, including minorities, women, protected veterans, and individuals with disabilities. Apple will not discriminate or retaliate against applicants who inquire about, disclose, or discuss their compensation or that of other applicants.

Apply Online

Charles River Laboratories, Mattawan, MI—Clinical Pathologist II

Posted:
Company: Charles River Laboratories
Location: Mattawan, MI
Job Title: Clinical Pathologist II

Description:
We are seeking an experienced Clinical Pathologist II for our Clinical Pathologist department in Mattawan MI.

The following are responsibilities related to the Clinical Pathologist II:

A Clinical Pathologist II is responsible for all aspects of clinical pathology conducted on research studies. Partner with Study Directors to provide comprehensive interpretation and preparation of the clinical pathology portions of reports. Participate in protocol development, measurement of hematology, coagulation, clinical chemistry, and urinanalytical parameters

The following are minimum requirements related to the Clinical Pathologist II position:

  • Education: D.V.M. / V.M.D. (Doctor of Veterinary Medicine) degree required. Ph.D. in Clinical Pathology or related discipline preferred.
  • Experience: Minimum 5 years related experience in clinical pathology or experimental pathology with demonstrated research capability as demonstrated by publications in peer-reviewed journals. Experience in the contract research or pharmaceutical industry with Postdoctoral experience or advanced/specialized education preferred. An equivalent combination of education and experience may be accepted as a satisfactory substitute for the specific education and experience listed above.
  • Certification/Licensure: Board certification by the American College of Veterinary Pathologists (D.A.C.V.P.) Specialty in Clinical Pathology required.
  • Other: Full understanding of regulatory requirements, Good Laboratory Practices (GLPs), site SOPs, and of study types assigned. Knowledge of applicable international guidelines for all types of toxicology studies. Demonstrate leadership skills as they pertain to intra- and interdepartmental initiatives, Sponsor interactions, and business development. Effective written and verbal communication skills. Ability to handle multiple projects, prioritize work and meet deadlines. Proficiency in the use of standard software including Microsoft® Excel, Word, PowerPoint, etc. and with standard laboratory calculations and statistical interpretation.

For more information, please visit www.criver.com.

Equal Employment Opportunity
Charles River Laboratories, Inc. is an Equal Opportunity Employer M/F/Disabled/Vet

Apply Online

  •  11190 Sunrise Valley Drive,
    Suite 300, Reston, VA 20191